What is cysteamine?Cysteamine is a licensed drug used in the treatment of cystinosis for more than 20 years. After a fortuitous observation, laboratory based work suggests that cysteamine may be a beneficial adjunct to conventional antibiotic treatment in CF. Cysteamine is a potent mucolytic, it disrupts biofilms, is antimicrobial, and synergises with other antibiotic agents, broadening their spectrum of activity, and reverses antibiotic resistance (even in multi-drug resistant bacteria). Although the pharmacokinetic characteristics of cysteamine are well established in people with cystinosis, there are no such data for cysteamine in CF. Recent studies, however, show promise for the use of cysteamine for treating patients with cystic fibrosis.
Why cysteamine for CF?
· Cysteamine as a mucolytic with antimicrobial properties