Why EGCG with Cysteamine for CF?


Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation.


"This cysteamine effect after washout was further sustained by the sequential administration of epigallocatechin gallate (EGCG), a green tea flavonoid, both in vivo, in mice, and in vitro, in primary epithelial cells from CF patients. "

"Altogether, these results suggest that optimal schedules of cysteamine plus EGCG might be used for the treatment of CF caused by the F508del-CFTR mutation."

Cystic Fibrosis Game Changer: New Strategy to Treat Inherited Disease

"Research carried out in Dundee over the past 15 years has shown than another overactive enzyme, a protein kinase called CK2, was present in CF patient cell biopsies. The consortium paired up with researchers at the University of Padua and next discovered that epigallocatechin gallate (EGCG), a green tea flavonoid already approved as an over-the-counter tonic, showed promise for preventing overactivity in CK2 in the test tube and this was given along with cysteamine to 10 patients who all had the same common type of CF. The combination of drugs reduced inflammation further and now reduced the levels of salt in the sweat in nine of the ten patients"

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